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Techniques for forming plasma-activated solutions for cancer therapy and other medical applications

  • Institute of Innovation for Future Society

Masaru Hori [Professor]

http://www.nuee.nagoya-u.ac.jp/labs/horilab/

Outline of Seeds

Purpose:
Based on a collaborative medical-engineering framework, our group is actively working on plasma cancer treatment research. Particularly, since it was discovered in recent years that plasma-irradiated solutions (called plasma-activated solutions) have an anti-tumor effect, we have been enthusiastically looking into medical applications for these substances.

Overview:
Through the joint projects with obstetrics and gynecology (OBGYN) and gastrointestinal surgery departments, we have been working on research and development to come up with peritoneal metastasis treatments in ovarian cancers, stomach cancers, and the like. We have also been working on joint projects with the Center for Advanced Medicine and Clinical Research at Nagoya University Hospital, the Department of Pathology and Biological Responses, and others for the purpose of elucidating a mechanism for selectively destroying cancer cells with plasma-activated solutions. Finally, we are engaged in a joint R&D project with the ophthalmology department on age-related macular degeneration.

Novelty and originality of this research

We have developed a unique plasma source that generate an atmospheric pressure plasma with a hundred times higher electron density by dielectric barrier discharge, and have already moved ahead with various applied medical research projects. We have seen new results in the several applications, including drug-resistant ovarian cancer in the OBGYN department, stomach cancer in the gastrointestinal surgery department, and treatment for age-related macular degeneration in the ophthalmology department. In the process, medical applications for plasma-activated solutions have greatly expanded.

Application and research area for Industry collaboration

Ripple effects in the local economy:
Plasma-activated solutions are expected to have ripple effects in the treatment of a variety of cases, including patients with refractory peritoneal metastasis. Additional major ripple effects include the significant impact that plasma-activated solutions are expected to have on the pharmaceutical industry as a new anticancer drug, while medical device manufacturers also stand to reap tremendous benefits through the development of devices that produce plasma-activated solutions.

Practical applications:
Our developments are applicable to joint research projects with medical device manufacturers as well as pharmaceutical companies. We expect to be able to practically apply our advances in the next five to ten years.

Keywords

Plasma-activated solution, cancer treatments