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  2. Noninvasive estimation of I-123 IMP arterial blood activity using I-123 IMP acquisition data from the lungs and brain and verification of its usefulness for quantification of regional cerebral blood flow

Noninvasive estimation of I-123 IMP arterial blood activity using I-123 IMP acquisition data from the lungs and brain and verification of its usefulness for quantification of regional cerebral blood flow

  • School of Medicine/Graduate School of Medicine
  • Department of Radiological and Medical Laboratory Sciences

Katsuhiko Kato [Professor]

Outline of Seeds

Regional cerebral blood flow (rCBF) can be measured by rCBF scintigraphy. Anatomical distribution and characteristics of deficits in rCBF are important clinical findings for pathological evaluation of cerebrovascular disorders, differential diagnosis of dementia, and detection of epileptic foci etc. Among the methods for rCBF quantification using I-123 IMP, the I-123 IMP autoradiography (ARG) method has been frequently used as a relatively simple and reliable method. However, the method still requires one-point arterial blood sampling by arterial puncture which is invasive for the patients to be examined by the methods. It is necessary to establish a simplified noninvasive method for rCBF quantification which is capable of giving reproducible and reliable accurate data. We devised a method without any blood sampling for estimating I-123 IMP arterial blood activity at 10 min after intravenous injection of I-123 IMP (Ca10), in which the multiple regression analysis was conducted to estimate Ca10 using the I-123 IMP acquisition data from dynamic images of the lungs and chronological static brain images in addition to conventional brain SPECT images. It has been confirmed that the estimated Ca10 values closely correlates with the directly measured Ca10 values, and the estimated Ca10 values are utilizable for rCBF quantification by the I-123 IMP ARG method as well as the directly measured Ca10 values.

Novelty and originality of this research

There were no reports in which the rCBF values estimated using I-123 IMP without any blood sampling were compared with those obtained by another method for rCBF quantification. The mean rCBF (mCBF) values calculated by the I-123 IMP ARG method using either the directly measured or the estimated Ca10 significantly correlated with those measured by O-15 H2O PET ARG method, showing better reliable results in comparison with previous results.

Key Takeaway

The regression equation for estimating Ca10 was established by using I-123 IMP acquisition data from dynamic images of the lungs and chronological static brain images in addition to conventional brain SPECT images. As a result, a noninvasive method for estimating Ca10 required for calculating rCBF by the I-123 IMP ARG method was established.

Keywords

regional cerebral blood flow (rCBF), 123I-IMP, Ca10, SPECT

Patents

  • Japanese Unexamined Patent Application Publication No. 2012-127814

Monographs, Papers and Articles

  • Validity of a Newly Developed Noninvasive Method for Estimating Cerebral Blood Flow Using 123I-IMP Acquisition Data from the Lungs and Brain. Medical Research Archives. Yusuke Fujita, Shinji Abe, Tetsuro Odagawa, Arisa Niwa, Saki Tsuchiya, Yumiko Koshiba, Naotoshi Fujita, Hidetaka Kono, Seiichi Yamamoto, Katsuhiko Kato. Medical Research Archives. 4(6),2016. DOI: http://dx.doi.org/10.18103/mra.v4i6.634
  • Estimation of regional cerebral blood flow using N-isopropyl-p-iodine-123 iodoamphetamine acquisition data from the lungs and brain: An improved noninvasive technique. Shinji Abe, Katsuhiko Kato, Yoshitake Takahashi, Naotoshi Fujita, Mitsuru Ikeda, Naotoshi Ota, Yasukazu Kajita, Seiichi Yamamoto, Shinji Naganawa. Nuklearmedizin. 2014;53(6):221-226.
  • Estimation of I-123 IMP arterial blood activity using I-123 IMP acquisition data from the lungs and brain without any blood sampling: Validation of its usefulness for quantification of regional cerebral blood flow. Shinji Abe, Katsuhiko Kato, Yoshitake Takahashi, Naotoshi Fujita, Masato Yamashita, Masaki Shinoda, Mitsuru Ikeda, Naotoshi Ohta, Yasukazu Kajita, Shinji Naganawa. Clin Nucl Med.2012;37(3):258-263.